Anti-YAP (S127) (YAP1, YAP65, Yorkie homolog, 65kD Yes-associated protein) (Azide Free) (Biotin)

Anti-YAP (S127) (YAP1, YAP65, Yorkie homolog, 65kD Yes-associated protein) (Azide Free) (Biotin)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
043943-Biotin.200 200 µl - -

3 - 19 Werktage*

993,00 €
 
Transcriptional regulator which can act both as a coactivator and a corepressor and is the... mehr
Produktinformationen "Anti-YAP (S127) (YAP1, YAP65, Yorkie homolog, 65kD Yes-associated protein) (Azide Free) (Biotin)"
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3). Applications: Suitable for use in Dot Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Dot Blot 1:500, Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Schlagworte: Anti-YAP1, Anti-YAP65, Anti-Yorkie homolog, Anti-65 kDa Yes-associated protein
Hersteller: United States Biological
Hersteller-Nr: 043943-Biotin

Eigenschaften

Anwendung: ELISA, Dot Blot
Antikörper-Typ: Polyclonal
Konjugat: Biotin
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Phospho-YAP-S127 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 119-133 amino acids surrounding S127 of human YAP.
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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