Anti-WNK1

Anti-WNK1
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-60739.60 60 µl -

7 - 16 Werktage*

198,00 €
E-AB-60739.120 120 µl -

7 - 16 Werktage*

317,00 €
E-AB-60739.200 200 µl -

7 - 16 Werktage*

525,00 €
 
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded... mehr
Produktinformationen "Anti-WNK1"
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined. Protein function: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide- sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition. [The UniProt Consortium]
Schlagworte: Anti-p65, Anti-hWNK1, Anti-Kinase deficient protein, Anti-Erythrocyte 65 kDa protein, Anti-Protein kinase with no lysine 1, Anti-Protein kinase lysine-deficient 1, Anti-Serine/threonine-protein kinase WNK1, WNK1 Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-60739

Eigenschaften

Anwendung: WB, IF
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse
Immunogen: Recombinant protein of human WNK1

Handhabung & Sicherheit

Lagerung: -20°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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