Anti-VTCN1 / B7H4, clone B7H4/1788

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-V8175SAF-100UG 100 µg - -

3 - 10 Werktage*

752,00 €
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. T cell activation and immune function are... mehr
Produktinformationen "Anti-VTCN1 / B7H4, clone B7H4/1788"
1 mg/ml in 1X PBS, BSA free, sodium azide free. T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer. Protein function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T- cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. [The UniProt Consortium]
Schlagworte: Anti-B7h.5, Anti-B7-H4, Anti-Protein B7S1, Anti-B7 homolog 4, Anti-T-cell costimulatory molecule B7x, Anti-Immune costimulatory protein B7-H4, Anti-V-set domain-containing T-cell activation inhibitor 1, VTCN1 Antibody / B7H4
Hersteller: NSJ Bioreagents
Hersteller-Nr: V8175SAF

Eigenschaften

Anwendung: ELISA, FC, IF, WB, IHC (paraffin)
Antikörper-Typ: Monoclonal
Klon: B7H4/1788
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: A recombinant human partial protein
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-VTCN1 / B7H4, clone B7H4/1788"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen