Anti-Ubiquilin 1

Aktion:

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*1 Angebot gültig bis zum 30.04.2019
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG56209.100 100 µl - -

6 - 14 Werktage

452,00 €
 
Protein function: Plays an important role in the regulation of different protein degradation... mehr
Produktinformationen "Anti-Ubiquilin 1"
Protein function: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and endoplasmic reticulum- associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Involved in the regulation of macroautophagy and autophagosome formation, required for maturation of autophagy- related protein LC3 from the cytosolic form LC3-I to the membrane- bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome- lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Isoform 1 and isoform 3 play a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently downregulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing. [The UniProt Consortium]
Schlagworte: Anti-DA41, Anti-UBQLN1, Anti-PLIC-1, Anti-hPLIC-1, Anti-Ubiquilin-1, Anti-Protein linking IAP with cytoskeleton 1
Hersteller-Nr: ARG56209100

Eigenschaften

Anwendung: IHC (paraffin), WB, ICC, IF
Antikörper-Typ: Polyclonal
Wirt: Rabbit
Reaktivität: Human, Mouse (Erwartet: Rat)
Immunogen: KLH-conjugated synthetic peptide around aa. 296-326 (Center) of Human Ubiquilin 1
MW: 62.5 kD
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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