Anti-TRAIL-R1 (Preservative-free) (TRAIL Receptor 1, DR4, APO2, TNFRSF10A, CD261)

TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB. Applications: Suitable for use in Immunocytochemistry, Immunoprecipitation, Blocking and Flow Cytometry. Other applications not tested. Recommended Dilution: Inhibition: blocks TRAIL-R1 mediated killing if applied in solution, Optimal dilutions to be determined by researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.