Anti-Topoisomerase II alpha / TOP2A, clone FB-20

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-RQ5364 100 µl - -

3 - 10 Werktage*

755,00 €
 
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. The TOP2A gene... mehr
Produktinformationen "Anti-Topoisomerase II alpha / TOP2A, clone FB-20"
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. The TOP2A gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [RefSeq] Protein function: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation. [The UniProt Consortium]
Schlagworte: Anti-TOP2, Anti-TOP2A, Anti-DNA topoisomerase 2-alpha, Anti-DNA topoisomerase II, alpha isozyme, Topoisomerase II alpha Antibody / TOP2A
Hersteller: NSJ Bioreagents
Hersteller-Nr: RQ5364

Eigenschaften

Anwendung: IHC (paraffin), WB
Antikörper-Typ: Monoclonal
Klon: FB-20
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: A synthetic peptide specific to human Topoisomerase II alpha / TOP2A
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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