Anti-TOP1

Anti-TOP1
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A302-589A-T 10 µl (2 µg) -

2 - 8 Werktage*

164,00 €
A302-589A 100 µl -

2 - 8 Werktage*

588,00 €
 
Protein function: Releases the supercoiling and torsional tension of DNA introduced during the... mehr
Produktinformationen "Anti-TOP1"
Protein function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter. [The UniProt Consortium]
Schlagworte: Anti-TOP1, EC=5.99.1.2, Anti-DNA topoisomerase I, Anti-DNA topoisomerase 1
Hersteller: Bethyl Laboratories
Hersteller-Nr: A302-589A

Eigenschaften

Anwendung: WB, IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human (Erwartet: rat)
Immunogen: synthetic peptide. The epitope recognized by A302-589A-T maps to a region between residue 100 and 150 of human DNA topoisomerase I using the numbering given in entry NP_003277.1 (GeneID 7150).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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