Anti-TNF (bovine) alpha monoclonal antibody (clone Do-TNF-alpha)

Anti-TNF (bovine) alpha monoclonal antibody (clone Do-TNF-alpha)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
WSC0839B-100 100 µg - -

3 - 8 Werktage*

223,00 €
 
The primary role of TNF alpha is in the regulation of immune cells. TNF alpha, being an... mehr
Produktinformationen "Anti-TNF (bovine) alpha monoclonal antibody (clone Do-TNF-alpha)"
The primary role of TNF alpha is in the regulation of immune cells. TNF alpha, being an endogenous pyrogen, is able to induce fever, to induce apoptotic cell death, to induce sepsis (through IL-1 & IL-6 production), to induce cachexia, induce inflammation, and to inhibit tumorigenesis and viral replication. Protein function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6. [The UniProt Consortium]
Schlagworte: Anti-TNF, Anti-TNFA
Hersteller: Kingfisher Biotech
Hersteller-Nr: WSC0839B

Eigenschaften

Anwendung: FC
Antikörper-Typ: Monoclonal
Klon: Do-TNF-alpha
Konjugat: No
Wirt: Mouse
Reaktivität: Bovine, Caprine, Ovine
Format: Culture Supernatant

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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