Anti-TLR7 (Toll Like Receptor-7)

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5). TLR7, like TLRs 3, 8, and 9, is localized in intracellular acidic compartments such as the phagolysosome (6) and will recognize some single-stranded RNA viruses such as vesicular stomatitis virus (VSV) and influenza virus (7). Activation of TLR7 by VSV results in stimulation of the immune response including IFNa secretion, suggesting the importance of TLR7 in virus recognition. Applications: Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 0.5-2ug/mL, Immunocytochemistry: 2ug/mL, Optimal dilutions to be determined by the researcher. Positive Control: Daudi cell lysate, Control Peptide: T8050-71A, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.