Anti-TLR5 (human), clone ABM22G1

Anti-TLR5 (human), clone ABM22G1
%
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Rabatt Preis
AG-20T-0304-C100 100 µg -

3 - 9 Werktage*

10 %
446,00 €
401,40 €
 
TLR5 (Toll-like Receptor 5) is a member of the Toll-like receptor (TLR) family which plays a... mehr
Produktinformationen "Anti-TLR5 (human), clone ABM22G1"
TLR5 (Toll-like Receptor 5) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR5 recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor, via a conserved region within flagellin, the D1 portion/domain. Binding of flagellin induces the dimerization of TLR5, which in turn recruits MyD88. The recruitment of MyD88 leads to subsequent activation of IRAK4, IRAK1, TRAF6 and eventually IkappaB kinases. Activation of IkappaB kinases mobilizes the nuclear factor NF-kappaB and stimulates many downstream gene expressions, which initiate the canonical proinflammatory pathway, including TNF-alpha production. TLR5 may play a role in inflammatory bowel disease (IBD). Lower levels of TLR5 expression have been found in patients exhibiting moderate to severe ulcerative colitis (UC). TLR5 is suggested to be possibly involved in HPV induced inflammation and subsequent cervical neoplasia formation. It has been reported that TLR5 expression is detected in both ovarian epithelium and ovarian cancer cell lines, suggesting a possible role of TLR5 in inflammation induced ovarian cancer onset. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus and susceptibility to legionnaire disease, highlighting the importance of TLR5 in microbial recognition particularly at the mucosal surface. Protein function: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. [The UniProt Consortium]
Schlagworte: Anti-TIL3, Anti-TLR5, Anti-Toll-like receptor 5, Anti-Toll/interleukin-1 receptor-like protein 3
Hersteller: AdipoGen Life Sciences
Hersteller-Nr: AG-20T-0304

Eigenschaften

Antikörper-Typ: Monoclonal
Klon: ABM22G1
Konjugat: No

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-TLR5 (human), clone ABM22G1"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen