Protein function: Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock, binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation. [The UniProt Consortium]
Anti-TIEG, Anti-KLF10, Anti-TIEG-1, Anti-EGR-alpha, Anti-Krueppel-like factor 10, Anti-TGFB-inducible early growth response protein 1, Anti-Transforming growth factor-beta-inducible early growth response protein 1
synthetic peptide. The epitope recognized by A302-015A-T maps to a region between residue 430 and 480 of human TGFB inducible early growth response using the numbering given in entry NP_005646.1 (GeneID 7071).