Anti-THOC5

Anti-THOC5
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A302-119A-T 20 µl (2 blots) -

3 - 9 Werktage

125,00 €
A302-119A-M 100 µl (10 blots) -

3 - 9 Werktage

290,00 €
A302-119A 100 µl (20 µg) -

3 - 9 Werktage

430,00 €
 
Protein function: Acts as component of the THO subcomplex of the TREX complex which is thought to... mehr
Produktinformationen "Anti-THOC5"
Protein function: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes, probably mediates association of the TREX and CFIm complexes. [The UniProt Consortium]
Schlagworte: Anti-THOC5, Anti-PP39.2, Anti-fSAP79, Anti-hTREX90, Anti-C22orf19, Anti-Placental protein 39.2, Anti-THO complex subunit 5 homolog, Anti-NF2/meningioma region protein pK1.3, Anti-Functional spliceosome-associated protein 79
Hersteller: Bethyl Laboratories
Hersteller-Nr: A302-119A-T

Eigenschaften

Anwendung: WB, IP, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse (Erwartet: Rat, Bovine)
Immunogen: synthetic peptide. The epitope recognized by A302-119A-T maps to a region between residue 25 and 75 of human THO complex 5 using the numbering given in entry NP_003669.4 (GeneID 8563).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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