Anti-TET3 (N2), clone 2B7

Anti-TET3 (N2), clone 2B7
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
AC-M1092-4a 100 µg - -

3 - 11 Werktage*

431,00 €
 
Preservative: 0.02% Thimerosal. Protein function: Dioxygenase that catalyzes the conversion of... mehr
Produktinformationen "Anti-TET3 (N2), clone 2B7"
Preservative: 0.02% Thimerosal. Protein function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. In addition to its role in DNA demethylation, also involved in the recruitment of the O- GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. [The UniProt Consortium]
Schlagworte: Anti-TET3, Anti-KIAA0401, Anti-Methylcytosine dioxygenase TET3
Hersteller: Abiocode
Hersteller-Nr: M1092-4a

Eigenschaften

Anwendung: WB, FC
Antikörper-Typ: Monoclonal
Klon: 2B7
Konjugat: No
Wirt: Mouse
Reaktivität: Human, Mouse
Immunogen: N-terminal region of human TET3
MW: 179 kD
Format: Ammonium Sulfate Precipitated

Datenbank Information

UniProt ID : O43151 | Finde Alternativen
Gene ID GeneID 200424 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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