Anti-TET3 (N1)

Anti-TET3 (N1)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
AC-R1092-1 100 µl - -

3 - 11 Werktage*

431,00 €
 
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC)... mehr
Produktinformationen "Anti-TET3 (N1)"
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Conversion into 5hmC initiates a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. [The UniProt Consortium]
Schlagworte: Anti-TET3, Anti-KIAA0401, Anti-Methylcytosine dioxygenase TET3
Hersteller: Abiocode
Hersteller-Nr: R1092-1

Eigenschaften

Anwendung: WB, IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse
Immunogen: N-terminal region of human TET3
MW: 179 kD
Format: Affinity Purified

Datenbank Information

UniProt ID : O43151 | Finde Alternativen
Gene ID GeneID 200424 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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