Anti-TET2 (N2)

Anti-TET2 (N2)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
AC-M1086-4a 100 µl - -

3 - 11 Werktage*

431,00 €
 
Preservative: 0.01% NaN3. Protein function: Dioxygenase that catalyzes the conversion of the... mehr
Produktinformationen "Anti-TET2 (N2)"
Preservative: 0.01% NaN3. Protein function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. [The UniProt Consortium]
Schlagworte: Anti-Tet2, Anti-Kiaa1546, Anti-Protein Ayu17-449, Anti-Methylcytosine dioxygenase TET2
Hersteller: Abiocode
Hersteller-Nr: M1086-4a

Eigenschaften

Anwendung: WB, FC
Antikörper-Typ: Monoclonal
Klon: 10F1
Konjugat: No
Wirt: Mouse
Reaktivität: Mouse
Immunogen: N-terminal region of mouse TET2
MW: 224 kD
Format: Affinity Purified

Datenbank Information

UniProt ID : Q4JK59 | Finde Alternativen
Gene ID GeneID 214133 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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