Anti-Survival Motor Neuron Protein (human), clone 7B10

Anti-Survival Motor Neuron Protein (human), clone 7B10
%
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Rabatt Preis
AG-20T-0003-C200 200 µg -

3 - 9 Werktage*

10 %
330,00 €
297,00 €
 
Monoclonal Antibody. Recognizes a sequence of up to 9 amino acids in the N-terminal domain of... mehr
Produktinformationen "Anti-Survival Motor Neuron Protein (human), clone 7B10"
Monoclonal Antibody. Recognizes a sequence of up to 9 amino acids in the N-terminal domain of human SMN. Isotype: Mouse IgG1. Clone: 7B10. Applications: IP, WB. Liquid. In PBS. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. It is expressed in a wide variety of tissues, including high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle and low levels in fibroblasts and lymphocytes. Mutations in SMN cause spinal muscular atrophy 1 (SMA1). Spinal muscular atrophy is a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. The antibody was used extensively to purify and characterize the macromolecular SMN complex from cultured human cells. The antibody binds with high affinity and specificity to its epitope, which comprises a sequence of up to 9 amino acids in the N-terminal part of human SMN. It allows the native elution of bound antigen with an excess of the cognate peptide. Via addition of the 7B10 epitope (TagIt epitope) to other proteins this purification strategy can also be exploited for purification of these fusion proteins and RNA-protein complexes from cells lacking this epitope on endogenous proteins, such as cells derived from C. elegans and Drosophila.
Schlagworte: Anti-SMN, Anti-SMN1, Anti-SMNC, Anti-SMN2, Anti-Gemin-1, Anti-Component of gems 1, Anti-Survival motor neuron protein
Hersteller: AdipoGen Life Sciences
Hersteller-Nr: AG-20T-0003

Eigenschaften

Anwendung: IP, WB
Antikörper-Typ: Monoclonal
Klon: 7B10
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: Recombinant human full-length survival motor neuron protein (SMN).
Format: Liquid

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-Survival Motor Neuron Protein (human), clone 7B10"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen