Anti-Stk4, CT (Stk4, Mst1, Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1,

Anti-Stk4, CT (Stk4, Mst1, Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1,
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
042413-FITC.200 200 µl - -

3 - 19 Werktage*

993,00 €
 
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and... mehr
Produktinformationen "Anti-Stk4, CT (Stk4, Mst1, Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1,"
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Applications: Suitable for use in Western Blot, FLISA, Recommended Dilution: FLISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. , , Note: Applications are based on unconjugated antibody.
Schlagworte: Anti-Stk4, Anti-Mst1, EC=2.7.11.1
Hersteller: United States Biological
Hersteller-Nr: 042413-FITC

Eigenschaften

Anwendung: FLISA, WB
Antikörper-Typ: Polyclonal
Konjugat: FITC
Wirt: Rabbit
Spezies-Reaktivität: mouse
Immunogen: Mouse Stk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-470 amino acids from the C-terminal region of Mouse Stk4.
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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