Anti-STAT1

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA000931.25 25 µl -

Fragen Sie uns nach der Lieferzeit

156,00 €
ATA-HPA000931.100 100 µl -

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363,00 €
 
Protein function: Signal transducer and transcription activator that mediates cellular responses... mehr
Produktinformationen "Anti-STAT1"
Protein function: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 86% and to rat: 87%
Schlagworte: Anti-STAT1, Anti-Transcription factor ISGF-3 components p91/p84, Anti-Signal transducer and activator of transcription 1-alpha/beta
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA000931

Eigenschaften

Anwendung: WB, IHC, ICC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: FQEDPIQMSM IIYSCLKEER KILENAQRFN QAQSGNIQST VMLDKQKELD SKVRNVKDKV MCIEHEIKSL EDLQDEYDFK CKTLQNREHE TNGVAKSDQK QEQLLLKKMY LMLDNKRKEV VHKIIELLNV TELTQNA (ATA-APrEST78215)

Datenbank Information

KEGG ID : K11220 | Passende Produkte
UniProt ID : P42224 | Passende Produkte
Gene ID : GeneID 6772 | Passende Produkte
Protein Atlas Nr. : ENSG00000115415

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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