Anti-SOX6

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA001923.25 25 µl -

Fragen Sie uns nach der Lieferzeit

156,00 €
ATA-HPA001923.100 100 µl -

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363,00 €
 
Protein function: Transcription factor that plays a key role in several developmental processes,... mehr
Produktinformationen "Anti-SOX6"
Protein function: Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation. Specifically binds the 5'- AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 96% and to rat: 96%
Schlagworte: Anti-Transcription factor SOX-6
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA001923

Eigenschaften

Anwendung: ICC, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: TYKPGDNYPV QFIPSTMAAA AASGLSPLQL QQLYAAQLAS MQVSPGAKMP STPQPPNTAG TVSPTGIKNE KRGTSPVTQV KDEAAAQPLN LSSRPKTAEP VKSPTS (ATA-APrEST86388)

Datenbank Information

KEGG ID : K09269 | Passende Produkte
UniProt ID : P35712 | Passende Produkte
Gene ID : GeneID 55553 | Passende Produkte
Protein Atlas Nr. : ENSG00000110693

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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