Anti-SNW1

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA002457.25 25 µl -

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156,00 €
ATA-HPA002457.100 100 µl -

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363,00 €
 
Protein function: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638,... mehr
Produktinformationen "Anti-SNW1"
Protein function: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Is required in the specific splicing of CDKN1A pre-mRNA, the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 99% and to rat: 98%
Schlagworte: Anti-SNW1, Anti-Nuclear protein SkiP, Anti-Ski-interacting protein, Anti-SNW domain-containing protein 1, Anti-Nuclear receptor coactivator NCoA-62
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA002457

Eigenschaften

Anwendung: ICC, IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse, Rat
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: RNLSRAAPDK RSKLQRNENR DISEVIALGV PNPRTSNEVQ YDQRLFNQSK GMDSGFAGGE DEIYNVYDQA WRGGKDMAQS IYRPSKNLDK DMYGDDLEAR IKTNRFVPDK EFSGSDRRQR GREGPVQFEE DPFGLDKF (ATA-APrEST70452)

Datenbank Information

KEGG ID : K06063 | Passende Produkte
UniProt ID : Q13573 | Passende Produkte
Gene ID : GeneID 22938 | Passende Produkte
Protein Atlas Nr. : ENSG00000100603

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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