Anti-SNAI1, clone CL3700

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ATA-AMAb91215.25 25 µl -

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156,00 €
ATA-AMAb91215.100 100 µl -

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363,00 €
 
Protein function: Involved in induction of the epithelial to mesenchymal transition (EMT),... mehr
Produktinformationen "Anti-SNAI1, clone CL3700"
Protein function: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920). The N- terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription. SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. [The UniProt Consortium] Validated by orthogonal and standard strategies. Buffer: The antibodies are delivered in 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 82% and to rat: 82%
Schlagworte: Anti-SNAH, Anti-SNAI1, Anti-Protein sna, Anti-Protein snail homolog 1, Anti-Zinc finger protein SNAI1
Hersteller: Atlas Antibodies
Hersteller-Nr: AMAb91215

Eigenschaften

Anwendung: ICC, IHC
Antikörper-Typ: Monoclonal
Klon: CL3700
Konjugat: No
Wirt: Mouse
Reaktivität: Human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: MPRSFLVRKP SDPNRKPNYS ELQDSNPE (ATA-APrEST93897)

Datenbank Information

KEGG ID : K05707 | Passende Produkte
UniProt ID : O95863 | Passende Produkte
Gene ID : GeneID 6615 | Passende Produkte
Protein Atlas Nr. : ENSG00000124216

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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