Anti-Smac (Diablo Homolog, Mitochondrial, Direct IAP-binding Protein with Low pI, Second Mitochondri

Anti-Smac (Diablo Homolog, Mitochondrial, Direct IAP-binding Protein with Low pI, Second Mitochondri
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
S1014-48M.100 100 µg - -

3 - 19 Werktage*

479,00 €
 
Recently, three different laboratories have identified a molecule, Smac/DIABLO, which binds with... mehr
Produktinformationen "Anti-Smac (Diablo Homolog, Mitochondrial, Direct IAP-binding Protein with Low pI, Second Mitochondri"
Recently, three different laboratories have identified a molecule, Smac/DIABLO, which binds with inhibitor of apoptosis proteins (IAPs) and neutralizes IP inhibition of effector caspases. Multiple IAP molecules, including c-IAP1, c-IAP2, XIAP, and survivin are able to bind Smac. Smac/DIABLO is a mitochondrial protein, which is released into cytosol during apoptosis. The function of Smac is similar to that of Drosophila apoptosis activating proteins Reaper, Hid and Grim, which have been proposed to function by neutralizing the activity of IAPs. Smac promotes caspase-3 and caspase-9 activation by removing inhibitors rather than directly acting on Apaf-1, procaspases, and cytochrome c. The full-length cDNA of Smac encodes an open reading frame of 239aa, predicting a protein with a molecular weight of 27kD. However, the mature protein purified from HeLa cells is only about 25kD. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: HeLa cell lysate, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Schlagworte: Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI, Anti-Second mitochondria-derived activator of caspase
Hersteller: United States Biological
Hersteller-Nr: S1014-48M

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: Synthetic peptide corresponding to aa226-239 of human Smac (Genbank accession no. AAF87716).
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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