Anti-SAP102 (Synapse-associated Protein 102, bA291O7.3, Discs Large Drosophila Homolog 3, Discs Larg

Anti-SAP102 (Synapse-associated Protein 102, bA291O7.3, Discs Large Drosophila Homolog 3, Discs Larg
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
S0093-05C.25 25 µg - -

3 - 19 Werktage*

342,00 €
S0093-05C.100 100 µg - -

3 - 19 Werktage*

469,00 €
 
Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein... mehr
Produktinformationen "Anti-SAP102 (Synapse-associated Protein 102, bA291O7.3, Discs Large Drosophila Homolog 3, Discs Larg"
Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein , family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal (1, 2). SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homolgy 3 domain and a guanylate kinase domain (3). All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with , the carboxy-terminal domain of the N-methyl-D- aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway (3, 4). SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains (3). In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 , Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Schlagworte: Anti-Dlgh3, Anti-SAP-102, Anti-Disks large homolog 3, Anti-Synapse-associated protein 102, Anti-PSD-95/SAP90-related protein 1
Hersteller: United States Biological
Hersteller-Nr: S0093-05C

Eigenschaften

Anwendung: IHC, IP, WB
Antikörper-Typ: Monoclonal
Klon: 10F763
Konjugat: No
Wirt: Mouse
Reaktivität: Human, Mouse, Rat
Immunogen: Fusion protein aa 1-120 of rat SAP102 (accession number Q62936).
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-SAP102 (Synapse-associated Protein 102, bA291O7.3, Discs Large Drosophila Homolog 3, Discs Larg"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen