Anti-RNF31 / ZIBRA, C-terminal

Anti-RNF31 / ZIBRA, C-terminal
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG63225.100 100 µg - -

6 - 14 Werktage*

784,00 €
 
Protein function: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates... mehr
Produktinformationen "Anti-RNF31 / ZIBRA, C-terminal"
Protein function: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF- induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types. [The UniProt Consortium]
Schlagworte: Anti-HOIP, Anti-RNF31, Anti-ZIBRA, EC=6.3.2.-, Anti-RING finger protein 31, Anti-HOIL-1-interacting protein, Anti-E3 ubiquitin-protein ligase RNF31, Anti-Zinc in-between-RING-finger ubiquitin-associated domain protein
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG63225

Eigenschaften

Anwendung: ELISA, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Goat
Spezies-Reaktivität: human (Erwartet: canine, swine)
Immunogen: C-EEVPLGQSIPRRRK
Format: Ammonium Sulfate Precipitated

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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