Anti-RNF31

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA048745.25 25 µl -

7 - 10 Werktage*

335,00 €
ATA-HPA048745.100 100 µl -

7 - 10 Werktage*

446,00 €
 
Protein function: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates... mehr
Produktinformationen "Anti-RNF31"
Protein function: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). Binds polyubiquitin of different linkage types (PubMed:23708998). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 94% and to rat: 95%
Schlagworte: Anti-HOIP, Anti-RING finger protein 31, Anti-HOIL-1-interacting protein, Anti-E3 ubiquitin-protein ligase RNF31, Anti-RING-type E3 ubiquitin transferase RNF31, Anti-Zinc in-between-RING-finger ubiquitin-associated domain protein
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA048745

Eigenschaften

Anwendung: ICC, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: ELALSLLQET PRNYELGDVV EAVRHSQDRA FLRRLLAQEC AVCGWALPHN RMQALTSCEC TICPDCFRQH FTIALKEKHI TDMVCPACGR PDLTDDTQLL SYFSTLDIQL RESLEPDAYA LFHKKLTEGV (ATA-APrEST70543)

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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