Anti-Ricin communis, B chain (RCA I, Castor bean)

Anti-Ricin communis, B chain (RCA I, Castor bean)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
R2031-52J.200 200 µg - -

3 - 19 Werktage*

598,00 €
 
The ricin toxin consists of two chains, A and B, covalently linked by a disulfide bond. The A... mehr
Produktinformationen "Anti-Ricin communis, B chain (RCA I, Castor bean)"
The ricin toxin consists of two chains, A and B, covalently linked by a disulfide bond. The A chain acts as a glycosidase that removes an adenine residue from the 28S rRNA. The area from which the adenine is removed is essential for binding of elongation factors, destroying it leaves the ribosome inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, much faster than the cell can replace them, meaning that a single ricin A chain can kill a cell. The B chain binds to complex carbohydrates on the cell surface to facilitate entry of the A chain into the cell. Without the B chain, the A chain has very low toxicity. Ricin is easily extracted from the castor bean (Ricinus communis), and the lethal dose for humans is very small. It is toxic when inhaled, ingested or injected and there is no known antidote, although a vaccine has been developed. Treatment is symptomatic and supportive, with long term organ damage likely in survivors. The ease of extraction and distribution makes it a potential candidate for biological warfare although it is less stable than other agents, such as anthrax. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Optimal dilution to be determined by researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Schlagworte: EC=3.2.2.22, Anti-Ricin B chain, Anti-Ricin A chain, Anti-Linker peptide, Anti-rRNA N-glycosidase
Hersteller: United States Biological
Hersteller-Nr: R2031-52J

Eigenschaften

Anwendung: ELISA, WB
Antikörper-Typ: Monoclonal
Klon: 9A200
Konjugat: No
Wirt: Mouse
Reinheit: Purified by Protein G affinity chromatography.
Format: Affinity Purified

Datenbank Information

UniProt ID : P02879 | Finde Alternativen
Gene ID GeneID 8287993 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C (-20°C Glycerol)
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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