Anti-RAD9A

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA006725.25 25 µl -

7 - 10 Werktage*

300,00 €
ATA-HPA006725.100 100 µl -

7 - 10 Werktage*

421,00 €
 
Protein function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a... mehr
Produktinformationen "Anti-RAD9A"
Protein function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 72% and to rat: 74%
Schlagworte: Anti-hRAD9, Anti-RAD9A, EC=3.1.11.2, Anti-DNA repair exonuclease rad9 homolog A, Anti-Cell cycle checkpoint control protein RAD9A
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA006725

Eigenschaften

Anwendung: ICC, IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: AIFTIKDSLL DGHFVLATLS DTDSHSQDLG SPERHQPVPQ LQAHSTPHPD DFANDDIDSY MIAMETTIGN EGSRVLPSIS LSPGPQPPKS PGPHSEEEDE AEPSTVPGTP PPKKFRSLFF GSILAPV (ATA-APrEST71088)

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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