Anti-Prostaglandin D Synthase (hematopoietic-type, mouse)

Anti-Prostaglandin D Synthase (hematopoietic-type, mouse)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay10004349-1 100 µg -

5 - 10 Werktage*

324,00 €
Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class... mehr
Produktinformationen "Anti-Prostaglandin D Synthase (hematopoietic-type, mouse)"
Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class of glutathione-S-transferases (GSTs) that catalyzes the conversion of PGH2 (Cay-17020) to PGD2 (Cay-12010), an eicosanoid that has numerous biological functions, including vasorelaxation, recruitment of inflammatory cells, and inhibition of platelet aggregation. There are two types of PGDS: lipocalin PGDS (L-PGDS, Cay-10006788, Cay-10006787, Cay-10010548) and hematopoietic PGDS (H-PGDS, Cay-10006593, Cay-10004347). H-PDGS is found in peripheral tissues and immune cells, including Th2 cells, antigen-presenting cells, mast cells, megakaryocytes, and eosinophils, where it is localized to the cytosol. H-PGDS activity is increased by a variety of stimuli, including LPS, anti-IgE antibodies, phorbol 12-myristate 13-acetate (TPA, Cay-10008014), ionomycin (Cay-10004974), and inflammatory cytokines such as IL-13, IL-3, or IL-4. siRNA silencing of Hpgds decreases LPS-induced production of PGD2 in mouse bone marrow-derived macrophages (BMDMs). Transgenic overexpression of HPGDS in mice increases croton oil-induced ear swelling and PGD2 production, and genome-wide deletion of Hpgds exacerbates hypotension and vascular permeability in a mouse model of anaphylaxis. H-PGDS protein levels are increased in the nasal mucosa of patients with allergic rhinitis, and HPGDS SNPs have been found in individuals with asthma. Cayman's Prostaglandin D Synthase (hematopoietic-type, mouse) Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes H-PGDS at 23 kDa from human and mouse samples. Synonyms: H-PGD Synthase, H-PGDS. Immunogen: Purified recombinant mouse H-PGDS. Formulation: 100 µg purified IgG in 100 µl PBS, pH 7.2, containing 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Storage Buffer: PBS, pH 7.2, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Rat. Isotype: IgG1. Applications: IHC and WB. UniProt Accession #: Q9JHF7. Origin: Animal/Rat.
Schlagworte: Anti-Gsts, Anti-H-PGDS, Anti-H-PGDS, Anti-GST class-sigma, Anti-GST class-sigma, Anti-Glutathione S-transferase, Anti-Glutathione S-transferase, Anti-Prostaglandin-H2 D-isomerase, Anti-Prostaglandin-H2 D-isomerase, Anti-Glutathione-dependent PGD synthase,
Hersteller: Cayman Chemical
Hersteller-Nr: 10004349


Anwendung: IHC, WB
Antikörper-Typ: Monoclonal
Konjugat: No
Wirt: Rat
Reaktivität: Mouse
Immunogen: Purified recombinant mouse H-PGDS
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier folgen Informationen zur Produktreferenz. mehr
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-Prostaglandin D Synthase (hematopoietic-type, mouse)"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen