Anti-Prostaglandin D Synthase (hematopoietic-type, mouse) Antiserum

Prostaglandin D synthase (PGD synthase) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGD synthase have been identified, namely the lipocalin-type enzyme (beta-trace) and the hematopoietic enzyme. Lipocalin-type PGD synthase is localized in the central nervous system and male genital organs of various mammals and the human heart. This enzyme has been identified as beta-trace, which is a major protein in human cerebrospinal fluid. Hematopoietic PGD synthase is widely distributed in the peripheral tissues and is localized in the antigen-presenting cells, mast cells, and megakaryocytes. This enzyme, which requires glutathione for activity, belongs to the sigma-class of glutathione S-transferases and is approximately 23 kDa in size. Cayman's PGD Synthase (hematopoietic-type, mouse) Polyclonal Antiserum can be used for immunohistochemistry and Western blot applications. The antiserum recognizes the PGD synthase (hematopoietic-type, mouse) at 23 kDa from human and mouse samples.