Anti-Prostaglandin D Synthase (hematopoietic-type)

Anti-Prostaglandin D Synthase (hematopoietic-type)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay160013-1 1 each -

6 - 10 Werktage*

422,00 €
 
Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class... mehr
Produktinformationen "Anti-Prostaglandin D Synthase (hematopoietic-type)"
Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class of glutathione-S-transferases (GSTs) that catalyzes the conversion of PGH2 (Cay-17020) to PGD2 (Cay-12010), an eicosanoid that has numerous biological functions, including vasorelaxation, recruitment of inflammatory cells, and inhibition of platelet aggregation. There are two types of PGDS: lipocalin PGDS (L-PGDS, Cay-10006788, Cay-10006787) and hematopoietic PGDS (H-PGDS, Cay-10006593). H-PGDS is found in peripheral tissues and immune cells, including Th2 cells, antigen-presenting cells, mast cells, megakaryocytes, and eosinophils, where it is localized to the cytosol. H-PGDS activity is increased by a variety of stimuli, including LPS, anti-IgE antibodies, phorbol 12-myristate 13-acetate (TPA, Cay-10008014), ionomycin (Cay-10004974), and inflammatory cytokines such as IL-13, IL-3, or IL-4. siRNA silencing of Hpgds decreases LPS-induced production of PGD2 in mouse bone marrow-derived macrophages (BMDMs). Transgenic overexpression of HPGDS in mice increases croton oil-induced ear swelling and PGD2 production, and genome-wide deletion of Hpgds exacerbates hypotension and vascular permeability in a mouse model of anaphylaxis. H-PGDS protein levels are increased in the nasal mucosa of patients with allergic rhinitis, and HPGDS SNPs have been found in individuals with asthma. Cayman's Prostaglandin D Synthase (hematopoietic-type, mouse) Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes H-PGDS at 23 kDa from human, baboon, mouse, and rat samples.Synonyms: H-PGDS, H-PGD Synthase. Immunogen: Synthetic peptide from the N-terminal region of human H-PGDS. MW: 23 kDa. Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Rabbit. Applications: WB. Cross Reactivity: (+) H-PGDS. UniProt Accession #: O60760. Origin: Animal/Rabbit.
Schlagworte: Anti-GSTS, Anti-H-PGDS, Anti-H-PGDS, Anti-GST class-sigma, Anti-GST class-sigma, Anti-Glutathione S-transferase, Anti-Glutathione S-transferase, Anti-Prostaglandin-H2 D-isomerase, Anti-Prostaglandin-H2 D-isomerase, Anti-Glutathione-dependent PGD synthase,
Hersteller: Cayman Chemical
Hersteller-Nr: 160013

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Immunogen: Synthetic peptide from the N-terminal region of human H-PGDS
Format: Solid

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H315, H319, H335
P-Sätze: P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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