Anti-PRKAG1

Anti-PRKAG1
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-14562.20 20 µl - -

7 - 16 Werktage*

80,00 €
E-AB-14562.60 60 µl - -

7 - 16 Werktage*

156,00 €
E-AB-14562.120 120 µl - -

7 - 16 Werktage*

262,00 €
E-AB-14562.200 200 µl - -

7 - 16 Werktage*

459,00 €
 
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase... mehr
Produktinformationen "Anti-PRKAG1"
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Protein function: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. [The UniProt Consortium]
Schlagworte: Anti-AMPKg, Anti-PRKAG1, Anti-AMPK gamma1, Anti-AMPK subunit gamma-1, Anti-5'-AMP-activated protein kinase subunit gamma-1, PRKAG1 Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-14562

Eigenschaften

Anwendung: WB, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse, Rat
Immunogen: Recombinant protein of human PRKAG1
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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