Anti-PPM1D, NT (Protein Phosphatase 1D, Protein Phosphatase 2C delta Isoform, PP2C-delta, p53-induce

Anti-PPM1D, NT (Protein Phosphatase 1D, Protein Phosphatase 2C delta Isoform, PP2C-delta, p53-induce
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
P9107-19C.200 200 µl - -

3 - 19 Werktage*

728,00 €
 
PPM1D is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are... mehr
Produktinformationen "Anti-PPM1D, NT (Protein Phosphatase 1D, Protein Phosphatase 2C delta Isoform, PP2C-delta, p53-induce"
PPM1D is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. The gene for this protein is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:1,000, Immunohistochemistry: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Schlagworte: EC=3.1.3.16, Anti-Protein phosphatase 1D, Anti-p53-induced protein phosphatase 1, Anti-Protein phosphatase 2C isoform delta, Anti-Protein phosphatase magnesium-dependent 1 delta
Hersteller: United States Biological
Hersteller-Nr: P9107-19C

Eigenschaften

Anwendung: ELISA, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Synthetic peptide selected from the N-terminal region of human PPM1D (KLH).
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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