Anti-POLH

Anti-POLH
Anti-POLH
   
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA006721.25 25 µl -

Fragen Sie uns nach der Lieferzeit

156,00 €
ATA-HPA006721.100 100 µl -

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363,00 €
 
Protein function: DNA polymerase specifically involved in the DNA repair by translesion synthesis... mehr
Produktinformationen "Anti-POLH"
Protein function: DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906, PubMed:24553286, PubMed:16357261). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'- deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'- dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 63% and to rat: 61%
Schlagworte: Anti-POLH, Anti-RAD30, Anti-RAD30 homolog A, Anti-DNA polymerase eta, Anti-Xeroderma pigmentosum variant type protein
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA006721

Eigenschaften

Anwendung: IHC, ICC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: PPLTMLFLCA TKFSASAPSS STDITSFLSS DPSSLPKVPV TSSEAKTQGS GPAVTATKKA TTSLESFFQK AAERQKVKEA SLSSLTAPTQ APMSNSPSKP SLPFQTSQST GTE (ATA-APrEST71086)

Datenbank Information

KEGG ID : K03509 | Passende Produkte
UniProt ID : Q9Y253 | Passende Produkte
Gene ID : GeneID 5429 | Passende Produkte
Protein Atlas Nr. : ENSG00000170734

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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