Anti-PODXL, clone CL0308

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-AMAb90667.25 25 µl -

7 - 10 Werktage*

300,00 €
ATA-AMAb90667.100 100 µl -

7 - 10 Werktage*

421,00 €
 
Protein function: Involved in the regulation of both adhesion and cell morphology and cancer... mehr
Produktinformationen "Anti-PODXL, clone CL0308"
Protein function: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro- adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin- dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. [The UniProt Consortium] Validated by orthogonal and standard strategies. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 43% and to rat: 41%. Epitope specificity: IHTKLPAKDVYERLK.
Schlagworte: Anti-PC, Anti-PCLP, Anti-PODXL, Anti-Gp200, Anti-PCLP-1, Anti-Podocalyxin, Anti-GCTM-2 antigen, Anti-Podocalyxin-like protein 1
Hersteller: Atlas Antibodies
Hersteller-Nr: AMAb90667

Eigenschaften

Anwendung: IHC, WB
Antikörper-Typ: Monoclonal
Klon: CL0308
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: LPETMSSSPT AASTTHRYPK TPSPTVAHES NWAKCEDLET QTQSEKQLVL NLTGNTLCAG GASDEKLISL ICRAVKATFN PAQDKCGIRL ASVPGSQTVV VKEITIHTKL PAKDVYERLK DKWDELKEAG VSDMKLGD (ATA-APrEST85156)

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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