Anti-PMP70

0.5mg/ml if reconstituted with 0.2ml sterile DI water. 70 kDa peroxisomal membrane protein (PMP70), also called ATP-binding cassette sub-family D member 3, is a protein that in humans is encoded by the ABCD3 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. The gene was assigned to human chromosome 1p21-p22 by in situ hybridization. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Protein function: Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome, the latter function is a crucial step in bile acid biosynthesis (PubMed:25168382). The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity (PubMed:11248239). [The UniProt Consortium]