Anti-phospho-alpha-Synuclein (Tyr133)

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-CABP1093.50 50 µl - -

9 - 20 Werktage*

352,00 €
G-CABP1093.100 100 µl - - -

9 - 20 Werktage*

448,00 €
 
Protein function: Neuronal protein that plays several roles in synaptic activity such as... mehr
Produktinformationen "Anti-phospho-alpha-Synuclein (Tyr133)"
Protein function: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:28288128, PubMed:30404828, PubMed:20798282, PubMed:26442590). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590). [The UniProt Consortium]
Schlagworte: Anti-phospho-SNCA, Anti-phospho-NACP, Anti-phospho-Alpha-synuclein, Anti-phospho-Non-A beta component of AD amyloid, Anti-phospho-Non-A4 component of amyloid precursor, Phospho-alpha-Synuclein-Y133 Rabbit pAb
Hersteller: Assay Genie
Hersteller-Nr: CABP1093

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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