Anti-phospho-EGFR (Tyr1148)

Anti-phospho-EGFR (Tyr1148)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG58237.50 50 µl - -

6 - 14 Werktage*

520,00 €
 
Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating... mehr
Produktinformationen "Anti-phospho-EGFR (Tyr1148)"
Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Plays a role in enhancing learning and memory performance. [The UniProt Consortium]
Schlagworte: Anti-phospho-EGFR, Anti-phospho-ERBB, EC=2.7.10.1, Anti-phospho-Proto-oncogene c-ErbB-1, Anti-phospho-Epidermal growth factor receptor, Anti-phospho-Receptor tyrosine-protein kinase erbB-1
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG58237

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Phospho specific peptide corresponding to residues surrounding Tyr1148 of Human EGFR
MW: 134 kD
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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