Anti-PAX5, clone rPAX5/2060

Anti-PAX5, clone rPAX5/2060
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-V3594-20UG 20 µg - -

3 - 10 Werktage*

332,00 €
NSJ-V3594-100UG 100 µg - -

3 - 10 Werktage*

752,00 €
 
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. The PAX5 gene is a... mehr
Produktinformationen "Anti-PAX5, clone rPAX5/2060"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding domain, known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. Protein function: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage- specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin- release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238). [The UniProt Consortium]
Schlagworte: Anti-PAX5, Anti-BSAP, Anti-Paired box protein Pax-5, Anti-B-cell-specific transcription factor, PAX5 Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: V3594

Eigenschaften

Anwendung: ELISA, WB
Antikörper-Typ: Monoclonal
Klon: rPAX5/2060
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: human recombinant protein
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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