Anti-Park7 / DJ-1, clone 4H4

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG52388.100 100 µl - -

6 - 14 Werktage*

662,00 €
 
Protein function: Protects cells against oxidative stress and cell death. Plays a role in... mehr
Produktinformationen "Anti-Park7 / DJ-1, clone 4H4"
Protein function: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells. [The UniProt Consortium]
Schlagworte: Anti-PARK7, EC=3.4.-.-, Anti-Oncogene DJ1, Anti-Protein DJ-1, Anti-Parkinson disease protein 7
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG52388

Eigenschaften

Anwendung: WB, IHC
Antikörper-Typ: Monoclonal
Klon: 4H4
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: rat
Immunogen: Full length recombinant human Park7 expressed in and purified from E. coli
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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