Anti-PA1

Anti-PA1
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A301-978A-T 20 µl (2 blots) -

3 - 9 Werktage

125,00 €
A301-978A-M 100 µl (10 blots) -

3 - 9 Werktage

290,00 €
A301-978A 100 µl (100 µg) -

3 - 9 Werktage

430,00 €
 
Protein function: Its association with the histone methyltransferase MLL2/MLL3 complex is... mehr
Produktinformationen "Anti-PA1"
Protein function: Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG, the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). [The UniProt Consortium]
Schlagworte: Anti-GAS, Anti-PAGR1, Anti-C16orf53, Anti-PTIP-associated protein 1, Anti-PAXIP1-associated protein 1, Anti-PAXIP1-associated glutamate-rich protein 1, Anti-Glutamate-rich coactivator interacting with SRC1
Hersteller: Bethyl Laboratories
Hersteller-Nr: A301-978A-T

Eigenschaften

Anwendung: WB, IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human (Erwartet: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, Small-eared Galago, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A301-978A-T maps to a region between residue 1 and 50 of human PTIP-associated 1 protein using the numbering given in entry NP_078792.1 (GeneID 79447).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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