Anti-p-p62 (pS403)

Anti-p-p62 (pS403)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F48757-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F48757-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes a multifunctional protein that... mehr
Produktinformationen "Anti-p-p62 (pS403)"
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. Protein function: Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin- 1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. [The UniProt Consortium]
Schlagworte: Anti-p60, Anti-ORCA, Anti-EBIAP, Anti-SQSTM1, Anti-Sequestosome-1, Anti-Ubiquitin-binding protein p62, Anti-EBI3-associated protein of 60 kDa, Anti-Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, p-p62 Antibody (pS403)
Hersteller: NSJ Bioreagents
Hersteller-Nr: F48757

Eigenschaften

Anwendung: Dot Blot, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: This p-p62 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS403 of human p62/SQSTM1.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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