Anti-Notch4 (Notch homolog 4, Drosophila, INT3)

Anti-Notch4 (Notch homolog 4, Drosophila, INT3)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
N5375-50.200 200 µg - -

3 - 19 Werktage*

615,00 €
Notch signaling plays a key role in the normal development of many tissues and cell types,... mehr
Produktinformationen "Anti-Notch4 (Notch homolog 4, Drosophila, INT3)"
Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Notch family members share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Multiple human notch proteins (Notch1, Notch2, Notch3 and Notch4) have been identified and they function as a receptors for membrane bound ligands. Notch signaling is also linked to tumorigenesis as first demonstrated by the identification of a recurrent t(7,9)(q34,q34.3) chromosomal translocation involving the human Notch1 gene that is found in a small subset of human pre-T-cell acute lymphoblastic leukemias (T-ALL). Since this discovery, aberrant Notch signaling has been suggested to be involved in a wide variety of human neoplasms. Notch4 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Notch4 may also be associated with susceptibility to schizophrenia in a small portion of cases. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 0.2-1ug/ml. Detects the Int-3/Notch 4 intracellular domain in lysates from lysates from human placenta. Human placenta was resolved by electrophoresis, tansferred to PVDF and probed with N5375-50. Proteins were visualized using an IgG (HRP) goat anti-rabbit secondary antibody and a chemiluminescence detection system., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Hersteller: United States Biological
Hersteller-Nr: N5375-50


Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse
Immunogen: His-tag fusion protein containing the C-terminus aa5708-6217 of murine Notch 4.
Reinheit: Purified by Protein A affinity chromatography.
Format: Affinity Purified

Datenbank Information

Handhabung & Sicherheit

Lagerung: -20°C (-20°C Glycerol)
Versand: +4°C (International: +4°C)
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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