Anti-NEMO/IKK-gamma

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
200-401-GM7 100 µg - -

6 - 10 Werktage*

684,00 €
 
Anti-NEMO is an IgG fraction antibody purified from monospecific antiserum by a multi-step... mehr
Produktinformationen "Anti-NEMO/IKK-gamma"
Anti-NEMO is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. This antibody detects human NEMO. Cross reactivity with NEMO from other sources is unknown. Protein function: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response, this function requires 'Lys-27'-linked polyubiquitination. [The UniProt Consortium]
Schlagworte: Anti-FIP3, Anti-NEMO, Anti-IKKG, Anti-IKBKG, Anti-FIP-3, Anti-IKKAP1, Anti-IKK-gamma, Anti-IkB kinase subunit gamma, Anti-NF-kappa-B essential modifier, Anti-NF-kappa-B essential modulator, Anti-I-kappa-B kinase subunit gamma
Hersteller: Rockland Immunochemicals
Hersteller-Nr: 200-401-GM7

Eigenschaften

Anwendung: ELISA, IP, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: recombinant protein of human NEMO.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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