Anti-NEDD8

NEDD8 (neural precursor cell expressed, developmentally down-regulated 8) is a protein-coding gene. Diseases associated with NEDD8 include glomuvenous malformation. GO annotations related to this gene include ubiquitin protein ligase binding. Protein function: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. [The UniProt Consortium]