Anti-Nedd4

Anti-Nedd4
Anti-Nedd4
   
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
600-401-B05S 25 µl - -

1 - 9 Werktage

132,00 €
600-401-B05 100 µg - -

1 - 9 Werktage

493,00 €
 
Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2... mehr
Produktinformationen "Anti-Nedd4"
Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR- 2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. [The UniProt Consortium]
Schlagworte: Anti-NEDD-4, EC=6.3.2.-, Anti-E3 ubiquitin-protein ligase NEDD4, Anti-Cell proliferation-inducing gene 53 protein, Anti-Neural precursor cell expressed developmentally down-regulated protein 4
Hersteller: Rockland Immunochemicals
Hersteller-Nr: 600-401-B05S

Eigenschaften

Anwendung: ELISA, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Horse, Macaque
Immunogen: synthetic peptide corresponding to an internal portion of the Nedd4 protein
MW: 115 kD
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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