Anti-NCOR1 (Nuclear Receptor Co-repressor 1, N-CoR, KIAA1047, N-CoR1, Nuclear Receptor Corepressor 1

Anti-NCOR1 (Nuclear Receptor Co-repressor 1, N-CoR, KIAA1047, N-CoR1, Nuclear Receptor Corepressor 1
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
N0555-04F.100 100 µg - -

3 - 19 Werktage*

706,00 €
 
NCOR1 (Nuclear receptor Co-Repressor 1) is a 270kD member of the NCoR family of molecules. It is... mehr
Produktinformationen "Anti-NCOR1 (Nuclear Receptor Co-repressor 1, N-CoR, KIAA1047, N-CoR1, Nuclear Receptor Corepressor 1"
NCOR1 (Nuclear receptor Co-Repressor 1) is a 270kD member of the NCoR family of molecules. It is widely expressed, being found in hepatocytes, intestinal crypt cells, neural stem cells, plus immature thymocytes and erythrocytes. NCOR1 is a transcriptional repressor. It forms a complex with HDAC3, TAB2 and ZBTB33, and interacts with a ligand-independent THR:RXR heterodimer bound to select gene promoters. Human NCOR1 is 2440aa in length. It possesses one N-terminal repression domain (aa1-312), two DNA-binding SANT domains (aa437-674) and a second repression domain (aa737-1004). Multiple Ser, Thr and Tyr phosphorylation sites exist that regulate complex dissociation. There are multiple potential splice variants. Short poly Lys motifs serve as substitutions for the C-terminal 1900-1910aa. There is also a 16aa insertion after Glu727, coupled to either a Ile substitution for aa1842-1961, or a six aa substitution for aa31-145. Over aa1770-1947, human NCOR1 shares 96% aa identity with mouse NCOR1. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot:1ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Schlagworte: Anti-Nuclear receptor corepressor 1
Hersteller: United States Biological
Hersteller-Nr: N0555-04F

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Sheep
Reaktivität: Human, Mouse, Rat
Immunogen: Purified, E.coli-derived recombinant human NCOR1. (aa1770-1947, Accession #O75376).
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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