Anti-mTOR Rabbit

Anti-mTOR Rabbit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay32224-100 100 µl -

6 - 10 Werktage*

480,00 €
 
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase and member of the PI3K-related... mehr
Produktinformationen "Anti-mTOR Rabbit"
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase and member of the PI3K-related kinase family with roles in the regulation of cell growth and metabolism. It is comprised of N-terminal tandemly repeated HEAT motifs that facilitate protein-protein interactions, a FRAP, ATM, and TRRAP (FAT) domain, an FKBP12-rapamycin binding (FRB) domain, a catalytic kinase domain, an autoinhibitory/repressor domain, and a FAT carboxy-terminal (FATC) domain that is essential to kinase activity. mTOR is ubiquitously expressed in the cytosol and is the catalytic subunit of mTOR complex 1 (mTORC1) and mTORC2, which have roles in aging, autophagy, stem cell and immune function, cellular senescence, and macromolecule biogenesis, and cell survival, cytoskeletal organization, and metabolism, respectively. It is a component of the PI3K/AKT/mTOR signaling pathway that acts as a junction point both upstream and downstream of AKT. Dysregulation of the mTOR signaling pathway is associated with various pathologies, including cancer, rheumatoid arthritis, epilepsy, neurodegenerative diseases, and diabetes. Cayman's mTOR Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: Mammalian Target of Rapamycin, Mechanistic Target of Rapamycin Kinase, RAFT1, RAPT1. Immunogen: Peptide corresponding to human mTOR. Clone Designation: RM274. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) mTOR.
Schlagworte: Mammalian Target of Rapamycin, Mechanistic Target of Rapamycin Kinase, RAFT1, RAPT1
Hersteller: Cayman Chemical
Hersteller-Nr: 32224

Eigenschaften

Anwendung: IHC, WB
Antikörper-Typ: Monoclonal
Klon: RM274
Konjugat: No
Wirt: Rabbit
Immunogen: Peptide corresponding to human mTOR
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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