Anti-MLH1 (Human Mul L Homologue, Familial Nonpolyposis Colin Cancer Type 2, COCA2, Colon Cancer Typ

Anti-MLH1 (Human Mul L Homologue, Familial Nonpolyposis Colin Cancer Type 2, COCA2, Colon Cancer Typ
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
M3949-60C.20 20 µl - -

3 - 19 Werktage*

395,00 €
M3949-60C.100 100 µl - -

3 - 19 Werktage*

696,00 €
 
Mismatch repair (MMR), a conserved process that involves correcting errors made during DNA... mehr
Produktinformationen "Anti-MLH1 (Human Mul L Homologue, Familial Nonpolyposis Colin Cancer Type 2, COCA2, Colon Cancer Typ"
Mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. MLH1 is the human homologue of the E. coli MMR gene mutL. MMR requires recognition of a base mismatch or insertion/deletion loop by a MutS homolog followed by recruitment of a MutL heterodimeric complex consisting of MLH1 and PMS1 (MutL-alpha), PMS2 (MutL-beta) or MLH3 (MutL-gamma). Other factors required for MMR in eukaryotes are EXO1, PCNA, RFC, RPA, DNA polymerases and DNA ligase (reviewed in 1). Inactivation of the MLH1 gene causes genome instability and redisposition to cancer (2-5). The MLH1 gene is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) (6). MLH1 also plays a role in meiotic recombination (7). Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight. , Immunoprecipitation: 1:200 , Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Schlagworte: Anti-MutL protein homolog 1, Anti-DNA mismatch repair protein Mlh1
Hersteller: United States Biological
Hersteller-Nr: M3949-60C

Eigenschaften

Anwendung: IP, WB
Antikörper-Typ: Monoclonal
Klon: 10E39(D38G9)
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, monkey
Immunogen: Synthetic peptide corresponding to residues near the amino terminus of human MLH1 protein (KLH-coupled).
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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