Anti-MLH1, clone SQab1716

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG65861.100 100 µl - -

6 - 14 Werktage*

528,00 €
 
Protein function: Heterodimerizes with PMS2 to form MutL alpha, a component of the... mehr
Produktinformationen "Anti-MLH1, clone SQab1716"
Protein function: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. [The UniProt Consortium]
Schlagworte: Anti-MLH1, Anti-COCA2, Anti-MutL protein homolog 1, Anti-DNA mismatch repair protein Mlh1
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG65861

Eigenschaften

Anwendung: IHC (paraffin)
Antikörper-Typ: Monoclonal
Klon: SQab1716
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: Synthetic peptide around the C-terminus of Human MLH1
MW: 84 kD
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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