Anti-MKI67 (Ki-67, KIA, TSG126)

Anti-MKI67 (Ki-67, KIA, TSG126)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
145526.100 100 µg - -

3 - 19 Werktage*

1.007,00 €
 
MKI67 (also Ki-67) is a 350-400kD nuclear protein that belongs to a molecular group comprised of... mehr
Produktinformationen "Anti-MKI67 (Ki-67, KIA, TSG126)"
MKI67 (also Ki-67) is a 350-400kD nuclear protein that belongs to a molecular group comprised of mitotic chromosome-associated proteins. Ki-67 was originally recognized as an antigen associated with the monoclonal Ki-67 antibody raised against Hodgkin's lymphoma nuclear material. Ki-67 is contextually expressed, being potentially found in all cells that are not in the Go phase of the cell cycle. Thus, MKI67 qualifies as a cell proliferation marker. Functionally, Ki-67 is known to interact with 160kD Hklp2, a protein that promotes centrosome separation and spindle bipolarity. It also directly interacts with NIFK, and apparently binds to UBF, thus playing a role in rRNA synthesis. Human MKI67 is 3256 amino acids (aa) in length. It contains one FHA domain (aa 8-98), followed by at least 24 utilized Ser/Thr phosphorylation sites and sixteen 120aa repeats (aa 1000-2928) that are interspersed with at least 90 additional utilized phosphorylation sites. There are two potential isoform variants. One isoform is 315-345kD in size and shows a deletion of aa136-495, while a second isoform contains a 58 aa substitution for aa1-513. Over aa3120-3256, human Ki-67 shares 46% aa sequence identity with the mouse ortholog to Ki-67. Applications: Suitable for use in ELISA and Immunocytochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Hersteller: United States Biological
Hersteller-Nr: 145526

Eigenschaften

Anwendung: ELISA, ICC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Sheep
Spezies-Reaktivität: human, mouse
Format: Affinity Purified

Datenbank Information

UniProt ID : P46013 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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